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The five Blue Zones are located in: Sardinia, Italy – home to the world's longest-lived men Okinawa, Japan – home to the world's longest-lived women Loma Linda, California – Seventh-day Adventist community that outlives the average American by a decade Ikaria, Greece – tiny island community with significantly reduced rates of common chronic illnesses Nicoya, Costa Rica – area where people are more than twice as likely as Americans to reach 90 years of age "These are the original Blue Zones," says McAfee

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It is characterized by gasdermin-mediated pore formation in the plasma membrane, followed by osmotic imbalance and cellular rupture